Tirana is a small capital and that single fact does most of the work in this decision. You can walk from the main square to the far side of the restaurant district in twenty minutes, the museums and the bunker sites are all inside the same ring, and taxis are cheap enough that a mistake costs the price of a coffee. What actually differs between the districts is how loud your street is at midnight, how much you pay, and whether the buildings around you are Ottoman, socialist or new.
The four options
Blloku, the former closed party district, now the densest concentration of bars and restaurants.
Around Skanderbeg Square, for the museums, the transport and the biggest hotels.
Rruga e Kavajes and the west, cheaper, more ordinary and entirely walkable.
Near the Grand Park, quieter, greener and a slightly longer walk in.
Not the outer districts, which are residential and cost you time daily.
Anywhere inside the ring road, which is the actual rule.
What each is like
Blloku: young, loud, expensive by Tirana standards, superb for eating.
The square: convenient, institutional, dead at night in the immediate blocks.
The west: local, cheap, real, and five minutes further from the bars.
By the park: calm, family friendly, good for a longer stay.
Everywhere: five to twenty five minutes on foot from everywhere else.
Everywhere: uneven pavements and assertive traffic.

Practical notes
Cash is still king in smaller places, though cards work in hotels and central restaurants.
Airport transfers run to the centre and are cheap; taxis are plentiful.
Traffic is heavy and pavements are uneven; walking is fine and needs attention.
Apartments are frequently better value than hotels, particularly for families.
July and August are hotter and pricier; the city empties towards the coast.
Noise is the single biggest accommodation variable here.
What to do from your base
The bunker museums, both of them, which are the best thing in the city.
The House of Leaves, the surveillance museum, which is small and excellent.
The Dajti cable car, for the view and the air.
The pyramid, rebuilt and reopened, which is worth seeing for what it now is.
Eating, which is the real pleasure of Tirana and is very cheap.
The Grand Park, for a morning walk before the heat.
Where this fits in an Albania trip
Two nights at the start, in the centre, before picking up a car or a bus south.
For what to actually do in the city, our guide to things to do in Tirana covers the ground.
For fitting it into a fixed window, our three days in Tirana guide covers the shape.
And for what happens after ten at night, our Tirana nightlife guide covers the districts.

The short version
Stay inside the ring road and everything is walkable, which makes this a choice about noise and price rather than location. Blloku for eating and drinking, the square for museums and transport, the west for cheapness, the park for quiet. Book an apartment if there are more than two of you. Ask which way the room faces and read reviews for the word noise. And give the city two nights at the start of the trip rather than one at the end.
